In 2025, the direction of aesthetic medicine is clear: people increasingly want natural, long-lasting, and skin-friendly treatment methods. Instead of passive filling, people want to activate the skin’s own regenerative capacity and build well-being from the inside out.
Polynucleotide treatments meet this need – a regenerative treatment that has been one of the most popular treatments in my clinic throughout the summer. And with good reason: the results are particularly impressive in smoothing the eye area, evening out skin texture, and strengthening sensitive skin.
Polynucleotides: a treatment that harnesses the biological intelligence of the skin
Polynucleotides (PN) are long DNA fragments that stimulate skin cells to regenerate and repair themselves. They support, among other things, the activity of fibroblasts (which produce collagen and elastin), the calming of inflammatory reactions, the restoration of the skin’s moisture balance, and the repair of tissue damage. In practice, this means healthier, firmer, and smoother-looking skin — without fillers or permanent changes to facial expressions.
In practice, this means healthier, firmer, and smoother-looking skin—without fillers or permanent changes to facial features.
Q: Why salmon DNA?
At Klinik Linnea, we use the Korean Rejuran® polynucleotide preparation, which is made from purified salmon sperm DNA.
Salmon DNA:
Is genetically compatible with human skin and very well tolerated
It is carefully purified to remove proteins and potential allergens
It contains a high concentration of biologically active polynucleotides that effectively and safely stimulate the skin’s own repair process
The product contains no additives, making it ideal for sensitive or reactive skin – especially when combined with other treatments, such as microneedling or Morpheus 8 treatment, which you can read more about here.
My own experience of the treatment
I would also like to share my personal experience, as I have undergone Rejura Healer treatment myself and have been genuinely impressed with the results on my own atopic skin. After just a few weeks, I noticed how the area around my eyes was revitalized, my skin felt smoother, and it had a clear, healthy glow. In addition, the skin recovers much faster than with other treatments, such as micro-needling, which is a sign that the skin’s defenses and repair mechanisms have been activated.
In my work with clients, I have seen the same effect time and time again – especially with texture problems, sensitivity, and scarred skin. The results have been tangible and customer feedback has been positive.
Really satisfied, especially as the lines around my eyes have disappeared.
Satisfied customer after the second Rejuran treatment
Q: Who is PN treatment suitable for?
Rejuran® polynucleotide treatment is suitable for almost anyone who:
-Want natural skin renewal and preventive treatment
-Want to soften small lines or improve skin texture
-Suffer from scars, dullness, or surface dryness
-Are looking for help for sensitive or irritated skin
-Want faster recovery after other treatments
Polynucleotide treatment is one of the few treatments that genuinely affects the “intelligence” of the skin – not just the surface. It does not fill or remain as a solid substance in the skin, but stimulates the body to function better itself.
At Klinik Linnea, we always create individualized treatment plans. If you are interested in PN treatment or would like to know more about combinations tailored to your skin, you are warmly welcome to a consultation.
Essi Luhta
Registered Nurse
Klinik Linnea
Sources
1. Lampridou S, Bassett S, Christopoulos G, et al. The effectiveness of polynucleotides in esthetic medicine: A systematic review. J Cosmet Dermatol. 2025.
2. Guida S, Provenzano E, et al. PN-HPT® combined with HA for nasolabial folds: split-face study. J Cosmet Dermatol. 2022.
3. Kang MJ, et al. Effectiveness of injectable polynucleotides for enlarged facial pores. 2024.
4. Choi S, et al. Use of injectable polynucleotides among Korean dermatologists.J Cosmet Dermatol. 2024.
